Membrane Protein Folding. Denaturation Experiments of Sodium Channel.
نویسندگان
چکیده
منابع مشابه
Inactivation of the sodium channel. I. Sodium current experiments
Inactivation of sodium conductance has been studied in squid axons with voltage clamp techniques and with the enzyme pronase which selectively destroys inactivation. Comparison of the sodium current before and after pronase treatment shows a lag of several hundred microseconds in the onset of inactivation after depolarization. This lag can of several hundred microseconds in the onset of inactiv...
متن کاملFolding kinetics of proteins and cold denaturation.
Folding kinetics of a lattice model of protein is studied. It uses the random energy model for the intrachain couplings and a temperature dependent free energy of solvation derived from a realistic hydration model of apolar solutes. The folding times are computed using Monte Carlo simulations in the region of the phase diagram where the chain occurs in the native structure. These folding times ...
متن کاملKinetics and Thermodynamics of Membrane Protein Folding
Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute about a third of the proteins encoded in k...
متن کاملPhase Transitions in a Protein Folding Channel
In 2008 P. Nurse advocated the pursuit of biological phenomena through information processing. Along these lines, we aim to explain some of the salient characteristics of the mapping between amino acid sequences to protein folds through an information theoretic lens. To this end, we propose a protein folding channel that maps protein sequences into two-dimensional self-avoiding walks (also call...
متن کاملHelical membrane protein folding, stability, and evolution.
Helical membrane protein folding and oligomerization can be usefully conceptualized as involving two energetically distinct stages-the formation and subsequent side-to-side association of independently stable transbilayer helices. The interactions of helices with the bilayer, with prosthetic groups, and with each other are examined in the context of recent evidence. We conclude that the two-sta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1994
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.34.101